Michael Birnbaum

Associate Professor of Biological Engineering, MIT

BIRNBAUM Michael is a co-lead PI of SMART CAMP. He is also the Immune Cell Cross-cut (Cross-cut B) captain.

Website (External Link)

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Featured CAMP Publications

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Wu T (NUS), Tan JHL (A*STAR-IMCB), Sin WX (SMART), Luah YH (SMART), Tan SY (A*STAR-IMCB), Goh M (A*STAR-IMCB), Birnbaum ME (MIT), Chen Q (A*STAR-IMCB), Cheow LF (NUS)

Cell Granularity Reflects Immune Cell Function and Enables Selection of Lymphocytes with Superior Attributes for Immunotherapy

Advanced Science, 2302175, 2023; Aug 06, 2023
2023

SMART CAMP Authors

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Khloe S. Gordon, Taeyoon Kyung, Caleb R. Perez, Patrick V. Holec, Azucena Ramos, Angela Q. Zhang, Yash Agarwal, Yunpeng Liu, Catherine E. Koch, Alina Starchenko, Brian A. Joughin, Douglas A. Lauffenburger, Darrell J. Irvine, Michael T. Hemann & Michael E. Birnbaum

Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains`

Nature Biomedical Engineering, 6, pp. 855–866; Jun 16, 2022
2022

SMART CAMP Authors

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Connor S Dobson, Anna N. Reich, Stephanie Gaglione, Blake E. Smith, Ellen J. Kim , Jiayi Dong, Larance Ronsard, Vintus Okonkwo, Daniel Lingwood, Michael Dougan , Stephanie K. Dougan & Michael E. Birnbaum

Antigen identification and high throughput interaction mapping by reprogramming viral entry

Nature Methods, 19, pp. 449-460; Apr 08, 2022
2022

SMART CAMP Authors

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Featured CAMP Presentations

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Wei-Xiang Sin, Narendra Suhas Jagannathan, Denise Bei Lin Teo, Faris Kairi, Dedy Sandikin, Ka-Wai Cheung, Yie Hou Lee, Rajeev J. Ram, Lisa Tucker-Kellogg, Michael E. Birnbaum

High-density microbioreactor process designed for automated point-of-care manufacturing of CAR T cells

15TH STEM CELL SOCIETY SINGAPORE SYMPOSIUM 2023; "STEM CELL INNOVATIONS IN RESEARCH AND HEALTHCARE", Singapore

SMART CAMP Authors

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Tan Kwan Zen Nicholas, Kwek Zeming Kerwin, Quek Kaiyun, Goh Chin Ren, Ng Zhi Heng Nicholas, Michael E. Birnbaum, Yunxin Chen, Francesca Lorraine Lim Wei Inng, Jongyoon Han

Rapid assessment of immunological response in post-infusion CAR-T patients using biophysical WBC analysis

microTAS 2023, , Katowice, Poland

SMART CAMP Authors

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Xiaolin Wu, Joshua Jebaraj Raymond, Yaoping Liu, Alexander Jeremias Odermatt, Wei-Xiang Sin, Denise Teo, Inn Chuan Ng, Michael Birnbaum, Timothy Lu, Jongyoon Han, Stacy Springs* and Hanry Yu*.

Multiplex Detection of Low Abundance Live Microorganisms Contamination in CAR-T cell manufacture using a Quantitative Digital Loop-mediated Isothermal Amplification Method

2023 Annual Conference of the Biomedical Engineering Society (BMES2023), Seattle, WA, USA.

SMART CAMP Authors

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Joshua Raymond, Xiaolin Wu, Yaoping Liu, Alexander Jeremias Odermatt, Wei-Xiang Sin, Denise Teo, Michael Birnbaum, Timothy Lu , Jongyoon Han, Stacy Springs, Hanry Yu

Multiplex Detection of Low Abundance Live Microorganisms Contamination in CAR-T cell manufacture using a Quantitative Digital Loop-mediated Isothermal Amplification Method

Singapore Cell & Gene Therapy Conference 2023, Singapore

SMART CAMP Authors

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Cheryl CHAN, Joanne LOH, Wei-Xiang SIN, Denise TEO, Michael BIRNBAUM, Rohan WILLIAMS, Stacy L. SPRINGS

One-day Cell-free Viral RNA Test for Detecting Adventitious Viruses and Endogenous Viral Reactivation

Singapore Cell & Gene Therapy Conference 2023, Singapore

SMART CAMP Authors

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Nicholas Ng Zhi Heng, Kerwin Kwek Zeming, Kai Yun Quek, Francesca Loraine Lim, Yunxin Chen, Chin Ren Goh, Faye Cheung Ka Wai, Sin Wei Xiang, Michael E. Birnbaum, Jongyoon Han

Rapid Label-Free Profiling and CAR-T Biophysical Morphologies for Continuous Monitoring

Singapore Cell & Gene Therapy Conference 2023, Singapore

SMART CAMP Authors

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Nicholas Tan Kwan Zen, Kerwin Kwek Zeming, Kai Yun Quek, Francesca Loraine Lim, Yunxin Chen, Chin Ren Goh, Nicholas Ng Zhi Heng, Michael E. Birnbaum, Jongyoon Han

Rapid Assessment of immunological response in post-infusion CAR-T patients using biophysical WBC analysis

Singapore Cell & Gene Therapy Conference 2023, Singapore

SMART CAMP Authors

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Kerwin Kwek Zeming, Kai Yun Quek, Wei-Xiang Sin, Ka-Wai Cheung, Michael E. Birnbaum, Jongyoon Han

Rapid Label-free Microfluidic Assay for Profiling Functional Phenotypes of CAR T Cells: Towards Enhanced Manufacturing Control

Singapore Cell & Gene Therapy Conference 2023, Singapore

SMART CAMP Authors

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Wei-Xiang SIN (SMART), Denise TEO (SMART), Kevin S. LEE (Erbi Biosystems Inc), Harry LEE (Erbi Biosystems Inc), Narendra Suhas JAGANNATHAN (Duke-NUS), Rajeev RAM (MIT), Lisa TUCKER-KELLOGG (Duke-NUS), Michael BIRNBAUM (MIT)

High Density CAR T Cell Culture with a 2-mL Continuous Perfusion Bioreactor

14th Stem Cell Society Singapore Symposium 2022, Singapore

SMART CAMP Authors

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Wei-Xiang SIN (SMART), Faye CHEUNG (SMART), Sandy LEE (A*STAR SIgN), Dedy SANDIKIN (SMART), Denise TEO (SMART), Faris KAIRI (SMART), Cheng-I WANG (A*STAR SIgN), Michael BIRNBAUM (MIT)

Characterization of LVV-Transduced, In Vitro-Expanded Anti-TIM3 CAR T Cells

14th Stem Cell Society Singapore Symposium 2022, Singapore

SMART CAMP Authors

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Kevin S. Lee (Erbi Biosystems Inc.), Wei-Xiang Sin (SMART), Michael Birnbaum (MIT)

Cell therapy process development with a 2 mL continuous perfusion bioreactor

27th ESACT Meeting, Lisbon, Portugal

SMART CAMP Authors

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Wei-Xiang Sin (SMART), Kevin S. Lee (Erbi Biosystems Inc.), Harry Lee (Erbi Biosystems Inc.), Michael Birnbaum (MIT)

High density CAR T cell culture with a 2 mL continuous perfusion bioreactor

SDCT-REMEDIS Cell Therapy Conference, Virtual (Singapore)

SMART CAMP Authors

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Kevin S. Lee (Erbi Biosystems Inc, Wei-Xiang Sin (SMART), Harry Lee (Erbi Biosystems Inc.), Michael Birnbaum (MIT)

Erbi Biosystems - Cell culture development with a 2 mL continuous perfusion bioreactor

Advancing Manufacture of Cell and Gene Therapies VII, Engineering Conference International, Coronado, CA, USA

SMART CAMP Authors

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Latest News

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Nov 29, 2023

CAMP researchers present their research work at 15TH STEM CELL SOCIETY SINGAPORE SYMPOSIUM 2023; "STEM CELL INNOVATIONS IN RESEARCH AND HEALTHCARE"

Nov 28, 2023

New contamination-detection test to improve T-cell therapy

Nov 15, 2023

SMART pioneers microfluidic method to optimise stem cell extraction for advanced cell therapies

2023

Oct 19, 2023

Best Oral Presentation Award to Jerome Tan at “Tissue Engineering and Regenerative Medicine – Asia Pacific” Conference, Hong Kong

Sep 29, 2023

The people behind SMART CAMP: James Strutt, Senior Postdoctoral Researcher

Media/Press Release

Jun 9, 2023

Generation Next: New Era of Excellence

News

Apr 1, 2023

Intra-CREATE Seed Collaboration Grant 2022

News

Nov 13, 2022

Harnessing Self-Renewing Cells for Treatment of Cartilage Damage

Event

Aug 1, 2022

CAMP Summer Workshop 2022 - Best Poster & Demo Award

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