Stacy L. Springs

Executive Director MIT Biomanufacturing Program (BioMAN) and Center for Biomedical Innovation (CBI)

Website (External Link)

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Featured CAMP Publications

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Xiaolin Wu (SMART), Xuanming Lou (NUS), Hanzhang Zhou (NUS), Joshua Jebaraj Raymond (SMART), Leng Gek Kwang (NUS), Francesca Yi Teng Ong (NUS), Stacy L. Springs (MIT/SMART), Hanry Yu (NUS/SMART))

Detection and absolute quantification biosensing tools for food authentication: CRISPR/Cas, digital CRISPR and beyond

Trends in Food Science & Technology, Volume 145, p. 104349; Mar 01, 2024
2024

SMART CAMP Authors

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James P. B. Strutt (SMART), Meenubharathi Natarajan (SMART), Elizabeth Lee (SMART), Denise Bei Lin Teo (SMART), Wei-Xiang Sin (SMART), Faye Ka-Wai Cheung (SMART), Marvin Chew (SMART), Khaing Thazin (SMART), Paul W. Barone (MIT), Jacqueline M. Wolfrum (MIT), Rohan B. H. Williams (NUS), Scott A. Rice (NTU), Stacy L. Springs (MIT),

Machine-learning based detection of adventitious microbes in T-cell therapy cultures using long read sequencing

ASM Microbiology Spectrum (Published online); Aug 30, 2023
2023

SMART CAMP Authors

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Jiayi Huang, Liang Cui, Meenubharathi Natarajan, Paul W. Barone, Jacqueline M. Wolfrum, Yie Hou Lee, Scott A. Rice, and Stacy L. Springs

The ratio of nicotinic acid to nicotinamide as a microbial biomarker for assessing cell therapy product sterility

Molecular Therapy: Methods & Clinical Development, 25, pp. 410-424; Jun 01, 2022
2022

SMART CAMP Authors

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Xiaolin Wu , Cheryl Chan, Stacy L. Springs, Yie Hou Lee, Timothy K. Lu, Hanry Yu

A warm start digital CRISPR/Cas-based method for the quantitative detection of nucleic acids

Analytica Chimia Acta, 1196, 339494; Mar 01, 2022
2022

SMART CAMP Authors

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Xiaolin Wu, Joshua K. Tay, Chuan Keng Goh, Cheryl Chan, Yie Hou Lee, Stacy L. Springs, De Yun Wang, Kwok Seng Loh, Timothy K. Lu, Hanry Yu

Digital CRISPR-based method for the rapid detection and absolute quantification of nucleic acids

Biomaterials, 274, 120876; Jul 01, 2021
2021

SMART CAMP Authors

Featured CAMP Presentations

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Xiaolin Wu, Joshua Raymond, Cheryl Chan, Yaoping Liu, Yie Hou Lee, Timothy Lu, Stacy Springs, Hanry Yu

Accelerating cell therapy safety: rapid and accurate absolute quantification of adventitious agents using digital CRISPR approaches and beyond

15TH STEM CELL SOCIETY SINGAPORE SYMPOSIUM 2023; "STEM CELL INNOVATIONS IN RESEARCH AND HEALTHCARE", Singapore

SMART CAMP Authors

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Shruthi Pandi Chelvam, Alice Ng Jie Ying, Huang Jiayi, Elizabeth Lee, Derrick Yong, Rajeev Ram, Stacy Springs, Rohan B.H. Williams

Anomaly Detection for Microbial Contamination in Mesenchymal Stromal Cell Culture

15TH STEM CELL SOCIETY SINGAPORE SYMPOSIUM 2023; "STEM CELL INNOVATIONS IN RESEARCH AND HEALTHCARE", Singapore

SMART CAMP Authors

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Xiaolin Wu, Joshua Raymond, Cheryl Chan, Yaoping Liu, Yie Hou Lee, Timothy Lu, Stacy Springs*, Hanry Yu*.

Accelerating biomanufacturing safety: rapid and accurate absolute quantification of adventitious agents using digital CRISPR approaches

Recent Advances in Fermentation Technology (RAFT15), Naples, FL, USA.

SMART CAMP Authors

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Yaoping Liu, Patrina Weilin Chua, Sharon Yan Han Ling, Joshua Raymond, James Strutt, Cheryl Siew Choo Chan, Peiying Ho, Megan Mcbee, Rohan Williams, Stacy L. Springs and Jongyoon Han

Electrostatic microfiltration-based enrichment of low-abundance bacteria from large-volume samples improves the detection performances of amplication-free Nanopore sequencing

microTAS 2023, , Katowice, Poland

SMART CAMP Authors

1

Xiaolin Wu, Joshua Raymond, Cheryl Chan, Yaoping Liu, Yie Hou Lee, Timothy Lu, Stacy Springs, Hanry Yu

Accelerating cell therapy safety: rapid and accurate absolute quantification of adventitious agents using digital CRISPR approaches and beyond

Singapore Cell & Gene Therapy Conference 2023, Singapore

SMART CAMP Authors

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Joshua Raymond, Xiaolin Wu, Yaoping Liu, Alexander Jeremias Odermatt, Wei-Xiang Sin, Denise Teo, Michael Birnbaum, Timothy Lu , Jongyoon Han, Stacy Springs, Hanry Yu

Multiplex Detection of Low Abundance Live Microorganisms Contamination in CAR-T cell manufacture using a Quantitative Digital Loop-mediated Isothermal Amplification Method

Singapore Cell & Gene Therapy Conference 2023, Singapore

SMART CAMP Authors

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Cheryl CHAN, Joanne LOH, Wei-Xiang SIN, Denise TEO, Michael BIRNBAUM, Rohan WILLIAMS, Stacy L. SPRINGS

One-day Cell-free Viral RNA Test for Detecting Adventitious Viruses and Endogenous Viral Reactivation

Singapore Cell & Gene Therapy Conference 2023, Singapore

SMART CAMP Authors

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Yaoping Liu, Sharon Yan Han Ling, Patrina Wei Lin Chua, Joshua Raymond, Xiaolin Wu, James Strutt, Peiying Ho, Megan Mcbee, Rohan Williams, Stacy L. Springs, Timothy K. Lu and Jongyoon Han

Electrostatic microfiltration-based enrichment of low-abundance bacteria from large-volume samples improves the detection performances of digital PCR and sequencing

ECCMID 2023 the 33rd European Congress of Clinical Microbiology & Infectious Diseases), Copenhagen, Denmark

SMART CAMP Authors

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Alice Ng, Jiayi Huang, Liang Cui, Joshua Raymond, Meenubharathi Natarajan, Yie Hou Lee, Stacy L. Springs

Detection of microbial contaminations using nicotinic acid to nicotinamide ratio as a critical quality attribute to determine sterility in cell therapy products

14th Stem Cell Society Singapore Symposium 2022, Singapore

SMART CAMP Authors

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Cheryl Chan (SMART), Rohan Williams (NTU), Stacy L. Springs (MIT)

Extracellular RNA Biomarkers for the Detection of Adventitious Virus Infection of Cells

14th Stem Cell Society Singapore Symposium 2022, Singapore

SMART CAMP Authors

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James P. B. Strutt (SMART), Meenubharathi Natarajan (SMART), Wei Xiang Sin (SMART), Elizabeth Lee (SMART), Paul W. Barone (MIT), Jacqueline M. Wolfrum (MIT), Rohan B. H. Williams (NTU), Scott A. Rice (NTU), Stacy L. Springs (MIT)

Machine-learning based detection of adventitious agents in T cell therapy cultures using long read sequencing

14th Stem Cell Society Singapore Symposium 2022, Singapore

SMART CAMP Authors

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Nicholas Tan (SMART), Kerwin Kwek (SMART), Quek Kai Yun (SMART), Teo Kim Leng (A*STAR BTI), Loberas Mavis Gayle Lumawag (NUS), Steve Oh (A*STAR BTI), Hou Han Wei (NTU) Jongyoon Han (MIT)

Mesenchymal stem cell enrichment augmented through microfluidics from bone marrow aspirate

14th Stem Cell Society Singapore Symposium 2022, Singapore

SMART CAMP Authors

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Yaoping Liu (SMART), Joshua Raymond (SMART), Xiaolin Wu (SMART), Stacy L. Springs (MIT), Timothy K. Lu (MIT), Hanry Yu (NUS) and Jongyoon Han (MIT, SMART)

Electrostatic Microfiltration Enriches Low-abundance Bacteria and Improves Downstream Detection

Micro Total Analysis Systems (MicroTAS 2022), Hangzhou, China

SMART CAMP Authors

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Cheryl Chan (SMART), Rohan Williams (SCELSE), Stacy L. Springs (MIT)

Detecting Adventitious Virus Infection of Cells Using Extracellular RNA Biomarkers

SDCT-REMEDIS Cell Therapy Conference, Virtual (Singapore)

SMART CAMP Authors

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Chelvam, S. P. (SMART), Lee, Elizabeth (SMART), Huang, J (SMART), Wu, Y. (A*STAR-BTI), Abdul Rahim (A*STAR-BTI), Rajeev Ram, R. (MIT), Yong, D. (A *STAR-SIMTech), & Springs, S. (MIT)

Anomaly detection for microbial contamination in mesenchymal stromal cell culture

ISCT: Cytotherapy 2022, Process development and manufacturing, San Francisco, USA

SMART CAMP Authors

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Jiayi Huang (SMART), Thiara Sana Ahmed (NUS), Maciej Baranski (SMART), Elizabeth Lee (SMART), Shruthi Pandi Chelvam (SMART), Ying Ying Wu (A*STAR-BTI), Rajeev Ram (MIT), Scott Rice (NTU), Derrick Yong (A*STAR-SIMTech), and Stacy Springs (MIT)

Machine Learning-Aided At-Line Detection of Bacterial marker NA for Cell Manufacturing

Frontiers in Optics/Laser Science 2021, Virtual, Washington, DC United States

SMART CAMP Authors