Copyright ©2023 SMART CAMP
Flagship Project 2
Safety CQA
Rapid critical quality attributes for safety of cell sources and cell therapy products, informing process analytic technologies and speeding product release
What ?
Rapid critical quality attributes for safety of cell sources and cell therapy products, informing process analytic technologies and speeding product release.
Why ?
Safety of cell therapy products is paramount in the process development and regulatory approval process. If the first goal is to do no harm, the basic expectation is that the medicine is free from contamination including microorganisms that occur naturally in the laboratory space and equipment used to manufacture the cell products. Here, regulatory science and engagement also plays a role, since product safety is a public health concern and the regulatory bodies sets the bar for what must be measured and / or reported.
What we do ?
FP2 focuses on novel approaches to rapidly detect contaminants, microbial and viral particles, in cells therapy products. We plan to develop multiple approaches and detection technologies in order to tailor for different cell therapeutic applications.
Highlights
Intra-CREATE Seed Collaboration Grant 2022
Electrostatic microfiltration enriches low-abundance bloodborne pathogens and improves downstream detection performance
Rapid Digital Crispr Approach (RADICA)
SMART Researchers Develop Method for Rapid, Accurate Detection of Viruses
Publications
Y. Liu (SMART), J. Raymond (SMART), X. Wu (SMART), P. Chua (SMART), S. Ling SMART), C. C. Chan (SMART), C. Chan (SMART), J. Loh (SMART), M. Song (Ng Ann Poly), M. Ong (Ng Ann Poly), P. Ho (SMART), M. E. McBee (SMART), S. Springs (MIT/SMART), H. Yu (NUS) and J. Han (MIT/SMART),
Electrostatic Microfiltration (EM) Enriches and Recovers Viable Microorganisms at Low-abundance in Large-volume Samples and Enhances Downstream Detection
2024
SMART CAMP Authors
Linwei He (NTU), Jerome Tan (NTU), Shi Yan Ng (ASTAR-IMCB), King Ho Holden Li (NTU), Jongyoon Han (MIT/SMART), Sing Yian Chew (NTU), and Han Wei Hou (NTU)
Label-Free Impedance Analysis of Induced Pluripotent Stem Cell-Derived Spinal Cord Progenitor Cells for Rapid Safety and Efficacy Profiling
2024
SMART CAMP Authors
Arjav Shah (MIT/SMART), Shakul Pathak (MIT), Kun Li (SMART), Slaven Garaj (NUS), Martin Z. Bazant (MIT), Ankur Gupta (University of Colorado), Patrick S. Doyle*
A universal approximation for conductance blockade in thin nanopore membranes
2024
SMART CAMP Authors
Xiaolin Wu (SMART), Xuanming Lou (NUS), Hanzhang Zhou (NUS), Joshua Jebaraj Raymond (SMART), Leng Gek Kwang (NUS), Francesca Yi Teng Ong (NUS), Stacy L. Springs (MIT/SMART), Hanry Yu (NUS/SMART))
Detection and absolute quantification biosensing tools for food authentication: CRISPR/Cas, digital CRISPR and beyond
2024
SMART CAMP Authors
James P. B. Strutt (SMART), Meenubharathi Natarajan (SMART), Elizabeth Lee (SMART), Denise Bei Lin Teo (SMART), Wei-Xiang Sin (SMART), Faye Ka-Wai Cheung (SMART), Marvin Chew (SMART), Khaing Thazin (SMART), Paul W. Barone (MIT), Jacqueline M. Wolfrum (MIT), Rohan B. H. Williams (NUS), Scott A. Rice (NTU), Stacy L. Springs (MIT),
Machine-learning based detection of adventitious microbes in T-cell therapy cultures using long read sequencing
2023
SMART CAMP Authors
Kun Li (SMART), Arjav Shah (MIT/SMART), Rajesh Kumar Sharma (NUS), Raymond Adkins (UCSB), Tihomir Marjanovic (NUS), Patrick S. Doyle (MIT/SMART), Slaven Garaj (NUS)
Metrology of Individual Small Viruses
2023
SMART CAMP Authors
Jiayi Huang, Liang Cui, Meenubharathi Natarajan, Paul W. Barone, Jacqueline M. Wolfrum, Yie Hou Lee, Scott A. Rice, and Stacy L. Springs
The ratio of nicotinic acid to nicotinamide as a microbial biomarker for assessing cell therapy product sterility
2022
SMART CAMP Authors
Xiaolin Wu , Cheryl Chan, Stacy L. Springs, Yie Hou Lee, Timothy K. Lu, Hanry Yu
A warm start digital CRISPR/Cas-based method for the quantitative detection of nucleic acids
2022
SMART CAMP Authors
Xiaolin Wu, Joshua K. Tay, Chuan Keng Goh, Cheryl Chan, Yie Hou Lee, Stacy L. Springs, De Yun Wang, Kwok Seng Loh, Timothy K. Lu, Hanry Yu
Digital CRISPR-based method for the rapid detection and absolute quantification of nucleic acids
2021
SMART CAMP Authors
Rajesh Kumar Sharma, Ishita Agrawal, Liang Dai, Patrick Doyle, Slaven Garaj
DNA Knot Malleability in Single-Digit Nanopores
2021
SMART CAMP Authors
Conference Presentations
Xiaolin Wu, Joshua Raymond, Cheryl Chan, Yaoping Liu, Yie Hou Lee, Timothy Lu, Stacy Springs, Hanry Yu
SMART CAMP Authors
2023
Shruthi Pandi Chelvam, Alice Ng Jie Ying, Huang Jiayi, Elizabeth Lee, Derrick Yong, Rajeev Ram, Stacy Springs, Rohan B.H. Williams
SMART CAMP Authors
2023
Xiaolin Wu, Joshua Raymond, Cheryl Chan, Yaoping Liu, Yie Hou Lee, Timothy Lu, Stacy Springs*, Hanry Yu*.
SMART CAMP Authors
2023
Yaoping Liu, Patrina Weilin Chua, Sharon Yan Han Ling, Joshua Raymond, James Strutt, Cheryl Siew Choo Chan, Peiying Ho, Megan Mcbee, Rohan Williams, Stacy L. Springs and Jongyoon Han
SMART CAMP Authors
2023
Xiaolin Wu, Joshua Jebaraj Raymond, Yaoping Liu, Alexander Jeremias Odermatt, Wei-Xiang Sin, Denise Teo, Inn Chuan Ng, Michael Birnbaum, Timothy Lu, Jongyoon Han, Stacy Springs* and Hanry Yu*.
SMART CAMP Authors
2023
Xiaolin Wu, Joshua Raymond, Cheryl Chan, Yaoping Liu, Yie Hou Lee, Timothy Lu, Stacy Springs, Hanry Yu
SMART CAMP Authors
2023
Joshua Raymond, Xiaolin Wu, Yaoping Liu, Alexander Jeremias Odermatt, Wei-Xiang Sin, Denise Teo, Michael Birnbaum, Timothy Lu , Jongyoon Han, Stacy Springs, Hanry Yu
SMART CAMP Authors
2023
Cheryl CHAN, Joanne LOH, Wei-Xiang SIN, Denise TEO, Michael BIRNBAUM, Rohan WILLIAMS, Stacy L. SPRINGS
SMART CAMP Authors
2023
Yaoping Liu, Sharon Yan Han Ling, Patrina Wei Lin Chua, Joshua Raymond, Xiaolin Wu, James Strutt, Peiying Ho, Megan Mcbee, Rohan Williams, Stacy L. Springs, Timothy K. Lu and Jongyoon Han
SMART CAMP Authors
2023
Alice Ng, Jiayi Huang, Liang Cui, Joshua Raymond, Meenubharathi Natarajan, Yie Hou Lee, Stacy L. Springs
SMART CAMP Authors
2022
Cheryl Chan (SMART), Rohan Williams (NTU), Stacy L. Springs (MIT)
SMART CAMP Authors
2022
Joshua Raymond (SMART), Xiaolin Wu (SMART), Yaoping Liu (SMART), Jongyoon Han (MIT), Timothy Lu (MIT), Hanry Yu (NUS)
SMART CAMP Authors
2022
Kun Li (SMART), Arjav Shah (MIT), Patrick Doyle (MIT), Slaven Garaj (NUS)
SMART CAMP Authors
2022
James P. B. Strutt (SMART), Meenubharathi Natarajan (SMART), Wei Xiang Sin (SMART), Elizabeth Lee (SMART), Paul W. Barone (MIT), Jacqueline M. Wolfrum (MIT), Rohan B. H. Williams (NTU), Scott A. Rice (NTU), Stacy L. Springs (MIT)
SMART CAMP Authors
2022
Yaoping Liu (SMART), Joshua Raymond (SMART), Xiaolin Wu (SMART), Stacy L. Springs (MIT), Timothy K. Lu (MIT), Hanry Yu (NUS) and Jongyoon Han (MIT, SMART)
SMART CAMP Authors
2022
Cheryl Chan (SMART), Rohan Williams (SCELSE), Stacy L. Springs (MIT)
SMART CAMP Authors
2022
Arjav Shah (MIT), Kun Li (SMART), Slaven Garaj (NUS), Patrick S. Doyle (MIT)
SMART CAMP Authors
2022
Kun Li (SMART), Arjav Shah*(MIT), Patrick S. Doyle (MIT), Slaven Garaj (NUS)
SMART CAMP Authors
2022
Chelvam, S. P. (SMART), Lee, Elizabeth (SMART), Huang, J (SMART), Wu, Y. (A*STAR-BTI), Abdul Rahim (A*STAR-BTI), Rajeev Ram, R. (MIT), Yong, D. (A *STAR-SIMTech), & Springs, S. (MIT)
SMART CAMP Authors
2022
Jiayi Huang (SMART), Thiara Sana Ahmed (NUS), Maciej Baranski (SMART), Elizabeth Lee (SMART), Shruthi Pandi Chelvam (SMART), Ying Ying Wu (A*STAR-BTI), Rajeev Ram (MIT), Scott Rice (NTU), Derrick Yong (A*STAR-SIMTech), and Stacy Springs (MIT)
SMART CAMP Authors
2021