Publications

CAMP Publications

CAMP works with academic labs, clinics, and companies to develop methods that identify, monitor, and manipulate the critical quality attributes of cells that correlate with positive therapeutic outcomes.

All Publications

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1

Meiqi Kang (SMART), Yanmeng Yang (SMART), Haifeng Zhang (NUS), Yuan Zhang (NUS), Yingnan Wu (NUS), Vinitha Denslin (NUS), Rashidah Binte Othman (SMART), Zheng Yang (NUS/SMART) and Jongyoon Han (MIT/SMART)

Comparative Analysis of Serum and Serum-Free Medium Cultured Mesenchymal Stromal Cells for Cartilage Repair

International J. of Molecular Sciences, 2024, 25, 10627. ; Oct 02, 2024
2024

SMART CAMP Authors

1

Ching Ann Tee (SMART), Daniel Ninio Roxby (SMART), Rashidah Othman (SMART), Vinitha Denslin (NUS), Kiseer Sideeq Bhat (SMART), Zheng Yang (NUS), Jongyoon Han (MIT/SMART), Lisa Tucker-Kellogg (Duke-NUS) & Laurie A. Boyer (MIT/SMART)

Metabolic modulation to improve MSC expansion and therapeutic potential for articular cartilage repair

Stem Cell Research & Therapy, Volume 15, Article number: 308 ; Sep 16, 2024
2024

SMART CAMP Authors

1

Ri Lu (NUS), Yan Shan Ang (NUS), Ka-Wai Cheung (SMART), Kai Yun Quek (SMART), Wei-Xiang Sin (SMART), Elizabeth Lee (SMART), Shir Lynn Lim (NUS), Lin-Yue Lanry Yung (NUS), Michael E. Birnbaum (MIT/SMART), Jongyoon Han (MIT/SMART), Lih Feng Cheow (NUS), Kerwin Kwek Zeming (SMART)

iSECRETE: Integrating Microfluidics and DNA Proximity Amplification for Synchronous Single-Cell Activation and IFN-𝜸 Secretion Profiling

Adv. Sci. 2024, 2309920; Aug 22, 2024
2024

SMART CAMP Authors

1

Y. Liu (SMART), J. Raymond (SMART), X. Wu (SMART), P. Chua (SMART), S. Ling SMART), C. C. Chan (SMART), C. Chan (SMART), J. Loh (SMART), M. Song (Ng Ann Poly), M. Ong (Ng Ann Poly), P. Ho (SMART), M. E. McBee (SMART), S. Springs (MIT/SMART), H. Yu (NUS) and J. Han (MIT/SMART),

Electrostatic Microfiltration (EM) Enriches and Recovers Viable Microorganisms at Low-abundance in Large-volume Samples and Enhances Downstream Detection

Lab Chip, 2024, DOI: 10.1039/D4LC00419A.; Aug 19, 2024
2024

SMART CAMP Authors

1

Linwei He (NTU), Jerome Tan (NTU), Shi Yan Ng (ASTAR-IMCB), King Ho Holden Li (NTU), Jongyoon Han (MIT/SMART), Sing Yian Chew (NTU), and Han Wei Hou (NTU)

Label-Free Impedance Analysis of Induced Pluripotent Stem Cell-Derived Spinal Cord Progenitor Cells for Rapid Safety and Efficacy Profiling

Adv. Mater. Technol., 2400589; Jul 05, 2024
2024

SMART CAMP Authors

1

Brandon Krupczak (MIT), Camille Farruggio (MIT) and Krystyn J. Van Vliet (MIT/SMART)

Manufacturing mesenchymal stromal cells in a microcarrier-microbioreactor platform can enhance cell yield and quality attributes: case study for acute respiratory distress syndrome

Journal of Translational Medicine (2024) 22:614; Jul 02, 2024
2024

SMART CAMP Authors

1

Hyungkook Jeon (MIT), Caleb R. Perez (MIT/SMART), Taeyoon Kyung (MIT), Michael E. Birnbaum (MIT/SMART), and Jongyoon Han (MIT/SMART)

Separation of Activated T Cells Using Multidimensional Double Spiral (MDDS) Inertial Microfluidics for High-Efficiency CAR T Cell Manufacturing

Analytical Chemistry; Jun 18, 2024
2024

SMART CAMP Authors

1

Wei-Xiang Sin (SMART), N. Suhas Jagannathan (SMART), Denise Bei Lin Teo (SMART), Faris Kairi (SMART), Shin Yie Fong (ASTAR-IMCB), Joel Heng Loong Tan (ASTAR-IMCB), Dedy Sandikin (SMART), Ka-Wai Cheung (SMART), Yen Hoon Luah (SMART), Xiaolin Wu (SMART), Joshua Jebaraj Raymond (SMART), Francesca Lorraine Wei Inng Lim (ACTRIS/SGH), Yie Hou Lee (SMART), Michaela Su-Fern Seng (SingHealth), Shui Yen Soh (SingHealth), Qingfeng Chen (ASTAR-IMCB), Rajeev J. Ram (SMART/MIT), Lisa Tucker-Kellogg (Duke-NUS) & Michael E. Birnbaum (SMART/MIT)

A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells

Nature Biomedical Engineering, Published online; Jun 04, 2024
2024

SMART CAMP Authors

1

Ekta Makhija (SMART), Yang Zheng (NUS), Jiahao Wang (NUS), Han Ren Leong (NUS), Rashidah Binte Othman (SMART), Ee Xien Ng (SMART), Eng Hin Lee (NUS), Lisa Tucker Kellogg (Duke-NUS), Yie Hou Lee (SMART), Hanry Yu (NUS), Zhiyong Poon (SGH), Krystyn J. Van Vliet (MIT/SMART)

Topological defects in self-assembled patterns of mesenchymal stromal cells in vitro are predictive attributes of condensation and chondrogenesis

PLOS ONE, 19(3): e0297769.; Mar 28, 2024
2024

SMART CAMP Authors

1

Arjav Shah (MIT/SMART), Shakul Pathak (MIT), Kun Li (SMART), Slaven Garaj (NUS), Martin Z. Bazant (MIT), Ankur Gupta (University of Colorado), Patrick S. Doyle*

A universal approximation for conductance blockade in thin nanopore membranes

Nano Letters 24, no. 16 (2024): 4766-4773. ; Mar 04, 2024
2024

SMART CAMP Authors

1

Xiaolin Wu (SMART), Xuanming Lou (NUS), Hanzhang Zhou (NUS), Joshua Jebaraj Raymond (SMART), Leng Gek Kwang (NUS), Francesca Yi Teng Ong (NUS), Stacy L. Springs (MIT/SMART), Hanry Yu (NUS/SMART))

Detection and absolute quantification biosensing tools for food authentication: CRISPR/Cas, digital CRISPR and beyond

Trends in Food Science & Technology, Volume 145, p. 104349; Mar 01, 2024
2024

SMART CAMP Authors

1

Tan Dai Nguyen (SMART), Wai Hon Chooi (ASTAR-IMCB), Hyungkook Jeon MIT), Jiahui Chen (NTU), Jerome Tan (NTU), Daniel N. Roxby (SMART), Cheryl Yi-Pin Lee (ASTAR-IMCB), Shi-Yan Ng (ASTAR-IMCB), Sing Yian Chew (NTU), Jongyoon Han (SMART/MIT)

Label-Free and High-Throughput Removal of Residual Undifferentiated Cells From iPSC-Derived Spinal Cord Progenitor Cells

Stem Cells Translational Medicine, Advance access publication, ; Feb 07, 2024
2024

SMART CAMP Authors

1

Zheng Yang (NUS/SMART) , Yingnan Wu (NUS), Shu Hui Neo (SMART), Dahou Yang (SMART), Hyungkook Jeon (MIT), Ching Ann Tee (SMART), Vinitha Denslin (NUS), Daryl Jimian Lin (NUS) , Eng Hin Lee (NUS), Laurie A Boyer (MIT/SMART), Jongyoon Han (MIT/SMART)

Size-Based Microfluidic-Enriched Mesenchymal Stem Cell Subpopulations Enhance Articular Cartilage Repair

The American Journal of Sports Medicine, 52(2), pp 503-515; Feb 01, 2024
2024

SMART CAMP Authors

1

Shu Hui Neo (SMART), Zhisheng Her (A*STAR-IMCB), Rashidah Othman (SMART), Ching Ann Tee (SMART), Li Ching Ong (Invivocue, Singapore), Yuehua Wang (Invivocue, Singapore), Irwin Tan (Invivocue, Singapore),Jaylen Tan (SMART), Yanmeng Yang (SMART), Zheng Yang (NUS), Qingfeng Chen (A*STAR-IMCB/NUS) and Laurie A. Boyer (MIT/SMART)

Expansion of human bone marrow-derived mesenchymal stromal cells with enhanced immunomodulatory properties

Stem Cell Research & Therapy (2023) 14:259; Sep 19, 2023
2023

SMART CAMP Authors

1

Nicholas Tan Kwan Zen (SMART), Kerwin Kwek Zeming (SMART), Teo Kim Leng (A*STAR-BTI), Mavis Loberas (NUS), Jialing Lee (NUS), Goh Chin Ren (SMART), Yang Dahou (SMART), Steve Oh (A*STAR-BTI), James Hui Hoi Po (NUS), Simon M. Cool (A*STAR-IMCB), Han Wei Hou (NTU), Jongyoon Han (MIT/SMART)

Scalable Mesenchymal Stem Cells Enrichment from Bone Marrow Aspirate View Article Online using Deterministic Lateral Displacement (DLD) Microfluidics Sorting

Lab on a Chip (Published online); Sep 01, 2023
2023

SMART CAMP Authors

1

James P. B. Strutt (SMART), Meenubharathi Natarajan (SMART), Elizabeth Lee (SMART), Denise Bei Lin Teo (SMART), Wei-Xiang Sin (SMART), Faye Ka-Wai Cheung (SMART), Marvin Chew (SMART), Khaing Thazin (SMART), Paul W. Barone (MIT), Jacqueline M. Wolfrum (MIT), Rohan B. H. Williams (NUS), Scott A. Rice (NTU), Stacy L. Springs (MIT),

Machine-learning based detection of adventitious microbes in T-cell therapy cultures using long read sequencing

ASM Microbiology Spectrum (Published online); Aug 30, 2023
2023

SMART CAMP Authors

1

Kun Li (SMART), Arjav Shah (MIT/SMART), Rajesh Kumar Sharma (NUS), Raymond Adkins (UCSB), Tihomir Marjanovic (NUS), Patrick S. Doyle (MIT/SMART), Slaven Garaj (NUS)

Metrology of Individual Small Viruses

Advanced Materials Interfaces, 2300385 ; Aug 17, 2023
2023

SMART CAMP Authors

1

Wu T (NUS), Tan JHL (A*STAR-IMCB), Sin WX (SMART), Luah YH (SMART), Tan SY (A*STAR-IMCB), Goh M (A*STAR-IMCB), Birnbaum ME (MIT), Chen Q (A*STAR-IMCB), Cheow LF (NUS)

Cell Granularity Reflects Immune Cell Function and Enables Selection of Lymphocytes with Superior Attributes for Immunotherapy

Advanced Science, 2302175, 2023; Aug 06, 2023
2023

SMART CAMP Authors

1

Ching Ann Tee (SMART), Jongyoon Han (MIT/SMART), Hoi Po James Hui (NUS), Eng Hin Lee (NUS/SMART), and Zheng Yang (NUS/SMART)

Perspective in achieving stratified articular cartilage repair using zonal chondrocytes

Tissue Engineering Part B: Reviews., 29 (3), pp. 310-330; Jun 07, 2023
2023

SMART CAMP Authors

1

Smitha Surendran Thamarath (SMART), Ching Ann Tee (SMART), Shu Hui Neo (SMART), Dahou Yang (SMART), Rashidah Othman (SMART), Laurie A Boyer (MIT/SMART), Jongyoon Han (MIT/SMART)

Rapid and Live-Cell Detection of Senescence in Mesenchymal Stem Cells by Micro Magnetic Resonance Relaxometry

Stem Cells Translational Medicine, 12 (5), pp. 266–280,; May 01, 2023
2023

SMART CAMP Authors

1

Zheng Li (MIT), Jin Xue (MIT), Marc de Cea (MIT), Jaehwan Kim (MIT/SMART), Hao Nong (GF, Singapore), Daniel Chong (GF, Singapore), Khee Yong Lim (GF, Singapore), Elgin Quek (GF, Singapore) & Rajeev J. Ram (MIT/SMART)

A sub-wavelength Si LED integrated in a CMOS platform

Nature Communications, 14, Article number: 882; Feb 16, 2023
2023

SMART CAMP Authors

1

Zhao, Z., Chen, X., Dowbaj, A.M., A Sljukic, Kaitlin Bratlie, Luda Lin, Eliza Li Shan Fong, Gowri Manohari Balachander, Zhaowei Chen, Alice Soragni, Meritxell Huch, Yi Arial Zeng, Qun Wang

Organoids

Nat Rev Methods Primers 2, 94; Dec 01, 2022
2022

SMART CAMP Authors

1

Iksung Kang, Marc de Cea, Jin Xue, Zheng Li, George Barbastathis, and Rajeev J. Ram

Simultaneous spectral recovery and CMOS micro-LED holography with an untrained deep neural network

Optica, 9 (10), pp. 1149-1155; Oct 01, 2022
2022

SMART CAMP Authors

1

Khloe S. Gordon, Taeyoon Kyung, Caleb R. Perez, Patrick V. Holec, Azucena Ramos, Angela Q. Zhang, Yash Agarwal, Yunpeng Liu, Catherine E. Koch, Alina Starchenko, Brian A. Joughin, Douglas A. Lauffenburger, Darrell J. Irvine, Michael T. Hemann & Michael E. Birnbaum

Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains`

Nature Biomedical Engineering, 6, pp. 855–866; Jun 16, 2022
2022

SMART CAMP Authors

1

Jiayi Huang, Liang Cui, Meenubharathi Natarajan, Paul W. Barone, Jacqueline M. Wolfrum, Yie Hou Lee, Scott A. Rice, and Stacy L. Springs

The ratio of nicotinic acid to nicotinamide as a microbial biomarker for assessing cell therapy product sterility

Molecular Therapy: Methods & Clinical Development, 25, pp. 410-424; Jun 01, 2022
2022

SMART CAMP Authors

1

Ching Ann Tee, Zheng Yang, Yingnan Wu, Xiafei Ren, Maciej Baranski, Daryl Jimian Lin, Afizah Hassan, Jongyoon Han, Eng Hin Lee

A Pre-Clinical Animal Study for Zonal Articular Cartilage Regeneration Using Stratified Implantation of Microcarrier Expanded Zonal Chondrocytes

Cartilage, April-June 2022, pp. 1-16; Apr 21, 2022
2022

SMART CAMP Authors

1

Connor S Dobson, Anna N. Reich, Stephanie Gaglione, Blake E. Smith, Ellen J. Kim , Jiayi Dong, Larance Ronsard, Vintus Okonkwo, Daniel Lingwood, Michael Dougan , Stephanie K. Dougan & Michael E. Birnbaum

Antigen identification and high throughput interaction mapping by reprogramming viral entry

Nature Methods, 19, pp. 449-460; Apr 08, 2022
2022

SMART CAMP Authors

1

Xiaolin Wu , Cheryl Chan, Stacy L. Springs, Yie Hou Lee, Timothy K. Lu, Hanry Yu

A warm start digital CRISPR/Cas-based method for the quantitative detection of nucleic acids

Analytica Chimia Acta, 1196, 339494; Mar 01, 2022
2022

SMART CAMP Authors

1

Sharvaj Kubal, Elizabeth Lee, Chor Yong Tay, Derrick Yong

Multitrack Compressed Sensing for Faster Hyperspectral Imaging, Sensors

Sensors, 21 (15), 5034; Jul 24, 2021
2021

SMART CAMP Authors

1

Chayakorn Petchakupa, Paul Edward Hutchinson, Hui Min Tay, Sheng Yuan Leong, King Ho Holden Li, Han Wei Hou

Label-free quantitative lymphocyte activation profiling using microfluidic impedance cytometry

Sensors and Actuators B: Chemical, 339, 129864; Jul 15, 2021
2021

SMART CAMP Authors

1

Xiaolin Wu, Joshua K. Tay, Chuan Keng Goh, Cheryl Chan, Yie Hou Lee, Stacy L. Springs, De Yun Wang, Kwok Seng Loh, Timothy K. Lu, Hanry Yu

Digital CRISPR-based method for the rapid detection and absolute quantification of nucleic acids

Biomaterials, 274, 120876; Jul 01, 2021
2021

SMART CAMP Authors

1

Kerwin Kwek Zeming, Rohan Vernekar, Mui Teng Chua, Kai Yun Quek, Greg Sutton, Timm Krüger, Win Sen Kuan, Jongyoon Han

Label‐Free Biophysical Markers from Whole Blood Microfluidic Immune Profiling Reveal Severe Immune Response Signatures

Small, 17 (12), 2006123; Mar 25, 2021
2021

SMART CAMP Authors

1

Lingyan Gong, Chayakorn Petchakup, Pujiang Shi, Pei Leng Tan, Lay Poh Tan, Chor Yong Tay, and Han Wei Hou

Direct and Label-Free Cell Status Monitoring of Spheroids and Microcarriers Using Microfluidic Impedance Cytometry

Small, 17 (21), 2007500; Mar 24, 2021
2021

SMART CAMP Authors

1

Rajesh Kumar Sharma, Ishita Agrawal, Liang Dai, Patrick Doyle, Slaven Garaj

DNA Knot Malleability in Single-Digit Nanopores

Nano Letters, 21 (9), pp. 3772-3779; Mar 04, 2021
2021

SMART CAMP Authors

1

Kerwin Kwek Zeming, Ri Lu, Kai Lee Woo, Guoyun Sun, Kai Yun Quek, Lih Feng Cheow, Chia-Hung Chen, Jongyoon Han, and Shir Lynn Lim

Multiplexed Single-Cell Leukocyte Enzymatic Secretion Profiling from Whole Blood Reveals Patient-Specific Immune Signature

Analytical Chemistry, 93 (10), pp. 4374–4382; Feb 18, 2021
2021

SMART CAMP Authors

1

Ng Ee Xien, Wang Ming, Neo Shu Hui, Tee Ching Ann, Chen Chia-Hung, Van Vliet Krystyn

Dissolvable gelatin-based microcarriers generated through droplet microfluidics for expansion and culture of mesenchymal stromal cells

Biotechnology Journal, 16 (3), 2000048; Oct 13, 2020
2020

SMART CAMP Authors

1

Kerwin Kwek Zeming, Yuko Sato, Lu Yin, Nai-Jia Huang, Lan Hiong Wong, Hooi Linn Loo, Ying Bena Lim, Chwee Teck Lim, Jianzhu Chen, Peter R. Preiser, and Jongyoon Han

Microfluidic label-free bioprocessing of human reticulocytes from erythroid culture

Lab on a Chip, 20, pp. 3445-3460; Aug 14, 2020
2020

SMART CAMP Authors

1

Guoyun Sun, Yao Teng, Zixuan Zhao, Lih Feng Cheow, Hanry Yu, and Chia-Hung Chen

Functional Stem Cell Sorting via Integrative Droplet Synchronization

Analytical Chemistry, 92 (11), 7915–7923; May 07, 2020
2020

SMART CAMP Authors

1

Lu Yin, Zheng Yang, Yingnan Wu, Vinitha Denslin, Chia Chen Yu, Ching Ann Tee, Chwee Teck Lim, Jongyoon Han, Eng Hin Lee

Label-free separation of mesenchymal stem cell subpopulations with distinct differentiation potencies and paracrine effects

Biomaterials, 40, 119881; May 01, 2020
2020

SMART CAMP Authors

1

Farah Tasnim, Nisha Hari Singh, Elijah Keng Foo Tan, Jiangwa Xing, Huan Li, Sebastien Hissette, Sravanthy Manesh, Justina Fulwood, Kapish Gupta, Chan Way Ng, Shuoyu Xu, Jeffrey Hill & Hanry Yu

Tethered primary hepatocyte spheroids on polystyrene multi-well plates for high-throughput drug safety testing

Scientific Reports, 10, Article number: 4768; Mar 16, 2020
2020

SMART CAMP Authors

1

Taehong Kwon, Sung Hee Ko, Jean-François P. Hamel, and Jongyoon Han

Continuous Online Protein Quality Monitoring during Perfusion Culture Production Using an Integrated Micro/Nanofluidic System

Analytical Chemistry, 2020, 92 (7), pp. 5267-5275; Mar 13, 2020
2020

SMART CAMP Authors

1

Ekta P. Makhija, Daniela Espinosa-Hoyos, Anna Jagielska, Krystyn J. Van Vliet

Mechanical regulation of oligodendrocyte biology

Neuroscience Letters, 717, 134673; Jan 02, 2020
2020

SMART CAMP Authors

1

Xiaozhong Huang, Fan Lee, Yao Teng, Corey Bryen Lingam, Zijian Chen, Min Sun, Ziwei Song, Gowri M. Balachandera, Hwa Liang Leo, Qiongyu Guo, Imran Shah, Hanry Yu

Sequential drug delivery for liver diseases

Advanced Drug Delivery Reviews, September–October issues, Volumes 149–150, pp. 72-84; Sep 01, 2019
2019

SMART CAMP Authors

1

George Barbastathis, Aydogan Ozcan, and Guohai Situ

On the use of deep learning for computational imaging

Optica, 6 (8), pp. 921-943; Jul 25, 2019
2019

SMART CAMP Authors