SMART researchers pioneer novel method to enhance effectiveness of MSC therapy for cartilage repair

SMART researchers have developed a novel method, including the application of a process analytical tool, that can be used to improve the efficacy of mesenchymal stromal cells (MSCs)-based therapy for articular cartilage repair

Tee Ching Ann

Postdoctoral Associate

Daniel Ninio Roxby

Research Fellow @ NTU

Rashidah Binte Othman

Senior Research Engineer

Kiesar Sideeq Bhat

Postdoctoral Associate

Jongyoon Han

Professor of Biological Engineering and Electrical Engineering, MIT

Laurie A. Boyer

Professor, Biology & Biological Engineering MIT

Researchers from the Critical Analytics for Manufacturing Personalized-Medicine (CAMP) Interdisciplinary Research Group (IRG) at Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, alongside collaborators from the National University of Singapore Tissue Engineering Programme (NUSTEP), have developed a novel method to enhance the ability of mesenchymal stromal cells (MSCs) to generate cartilage tissue by adding ascorbic acid (AA) during MSC expansion. The research also discovered that micro magnetic resonance relaxometry (µMRR), a novel process analytical tool (PAT) developed by SMART CAMP, can be used as a rapid, label-free process-monitoring tool for the quality expansion of MSCs.

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SMART researchers pioneer novel method to enhance effectiveness of MSC therapy for cartilage repair

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