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May 28, 2024
SMART discovers novel method to predict effectiveness of mesenchymal stromal cells (MSCs) for cartilage repair
SMART researchers have developed a new method to assess the potential of mesenchymal stromal cells (MSCs) to repair cartilage. This method is faster (9 days) compared to the current standard (21 days) and uses a simpler 2D culture system The new method analyses specific fingerprint-like patterns or topological defects in MSCs to predict how effective they will be for cartilage repair therapy This new method is non-destructive and also more accurate than existing ones, allowing researchers to identify effective cell batches and enable the development of new and more efficient cartilage regeneration therapies
Researchers from Critical Analytics for Manufacturing Personalized-medicine (CAMP) Interdisciplinary Research Group (IRG) at Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, and collaborators from the National University of Singapore Tissue Engineering Programme (NUSTEP) have discovered a more efficient method for evaluating the ability of mesenchymal stromal cells (MSCs) to regenerate cartilage. Their novel method is also the first to utilise topological defects in the self-assembly of MSCs to forecast their cartilage regeneration potential.
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