Michael Birnbaum

Associate Professor of Biological Engineering, MIT

BIRNBAUM Michael is a co-lead PI of SMART CAMP. He is also the Immune Cell Cross-cut (Cross-cut B) captain.

Website (External Link)

right-arrow

Featured CAMP Publications

1

Ri Lu (NUS), Yan Shan Ang (NUS), Ka-Wai Cheung (SMART), Kai Yun Quek (SMART), Wei-Xiang Sin (SMART), Elizabeth Lee (SMART), Shir Lynn Lim (NUS), Lin-Yue Lanry Yung (NUS), Michael E. Birnbaum (MIT/SMART), Jongyoon Han (MIT/SMART), Lih Feng Cheow (NUS), Kerwin Kwek Zeming (SMART)

iSECRETE: Integrating Microfluidics and DNA Proximity Amplification for Synchronous Single-Cell Activation and IFN-𝜸 Secretion Profiling

Adv. Sci. 2024, 2309920; Aug 22, 2024
2024

SMART CAMP Authors

Read Publication (External Link)

right-arrow

1

Hyungkook Jeon (MIT), Caleb R. Perez (MIT/SMART), Taeyoon Kyung (MIT), Michael E. Birnbaum (MIT/SMART), and Jongyoon Han (MIT/SMART)

Separation of Activated T Cells Using Multidimensional Double Spiral (MDDS) Inertial Microfluidics for High-Efficiency CAR T Cell Manufacturing

Analytical Chemistry; Jun 18, 2024
2024

SMART CAMP Authors

Read Publication (External Link)

right-arrow

1

Wei-Xiang Sin (SMART), N. Suhas Jagannathan (SMART), Denise Bei Lin Teo (SMART), Faris Kairi (SMART), Shin Yie Fong (ASTAR-IMCB), Joel Heng Loong Tan (ASTAR-IMCB), Dedy Sandikin (SMART), Ka-Wai Cheung (SMART), Yen Hoon Luah (SMART), Xiaolin Wu (SMART), Joshua Jebaraj Raymond (SMART), Francesca Lorraine Wei Inng Lim (ACTRIS/SGH), Yie Hou Lee (SMART), Michaela Su-Fern Seng (SingHealth), Shui Yen Soh (SingHealth), Qingfeng Chen (ASTAR-IMCB), Rajeev J. Ram (SMART/MIT), Lisa Tucker-Kellogg (Duke-NUS) & Michael E. Birnbaum (SMART/MIT)

A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells

Nature Biomedical Engineering, Published online; Jun 04, 2024
2024

SMART CAMP Authors

Read Publication (External Link)

right-arrow

1

Wu T (NUS), Tan JHL (A*STAR-IMCB), Sin WX (SMART), Luah YH (SMART), Tan SY (A*STAR-IMCB), Goh M (A*STAR-IMCB), Birnbaum ME (MIT), Chen Q (A*STAR-IMCB), Cheow LF (NUS)

Cell Granularity Reflects Immune Cell Function and Enables Selection of Lymphocytes with Superior Attributes for Immunotherapy

Advanced Science, 2302175, 2023; Aug 06, 2023
2023

SMART CAMP Authors

Read Publication (External Link)

right-arrow

1

Khloe S. Gordon, Taeyoon Kyung, Caleb R. Perez, Patrick V. Holec, Azucena Ramos, Angela Q. Zhang, Yash Agarwal, Yunpeng Liu, Catherine E. Koch, Alina Starchenko, Brian A. Joughin, Douglas A. Lauffenburger, Darrell J. Irvine, Michael T. Hemann & Michael E. Birnbaum

Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains`

Nature Biomedical Engineering, 6, pp. 855–866; Jun 16, 2022
2022

SMART CAMP Authors

Read Publication (External Link)

right-arrow

1

Connor S Dobson, Anna N. Reich, Stephanie Gaglione, Blake E. Smith, Ellen J. Kim , Jiayi Dong, Larance Ronsard, Vintus Okonkwo, Daniel Lingwood, Michael Dougan , Stephanie K. Dougan & Michael E. Birnbaum

Antigen identification and high throughput interaction mapping by reprogramming viral entry

Nature Methods, 19, pp. 449-460; Apr 08, 2022
2022

SMART CAMP Authors

Read Publication (External Link)

right-arrow

Featured CAMP Presentations

1

Sin, WX. (SMART), Jagannathan, N.S.(SMART, Duke-NUS), Teo, D.B.L. (SMART), Kairi F. (SMART), Fong S.Y. (IMCB, A*STAR), Tan J.H.L.** (IMCB, A*STAR), Sandikin D. (SMART), Cheung K.W.** (SMART), Luah Y.H.** (SMART), Wu X.** (SMART), Raymond J.J. (SMART), Lim F.L.W.I. (SGH, SingHealth), Lee Y.H. (SMART), Seng M.S.F. (KKH, SingHealth), Soh S.Y. (KKH, SingHealth), Chen Q. (IMCB, A*STAR), Ram R.J. (MIT), Tucker-Kellogg L. (Duke-NUS), Birnbaum M.E. (MIT)

A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells

Singapore Cell and Gene Therapy Pan Asia Summit 2024, Singapore

SMART CAMP Authors

Read Publication (External Link)

right-arrow

1

Wei-Xiang Sin, Narendra Suhas Jagannathan, Denise Bei Lin Teo, Faris Kairi, Dedy Sandikin, Ka-Wai Cheung, Yie Hou Lee, Rajeev J. Ram, Lisa Tucker-Kellogg, Michael E. Birnbaum

High-density microbioreactor process designed for automated point-of-care manufacturing of CAR T cells

15TH STEM CELL SOCIETY SINGAPORE SYMPOSIUM 2023; "STEM CELL INNOVATIONS IN RESEARCH AND HEALTHCARE", Singapore

SMART CAMP Authors

Read Publication (External Link)

right-arrow

1

Tan Kwan Zen Nicholas, Kwek Zeming Kerwin, Quek Kaiyun, Goh Chin Ren, Ng Zhi Heng Nicholas, Michael E. Birnbaum, Yunxin Chen, Francesca Lorraine Lim Wei Inng, Jongyoon Han

Rapid assessment of immunological response in post-infusion CAR-T patients using biophysical WBC analysis

microTAS 2023, , Katowice, Poland

SMART CAMP Authors

Read Publication (External Link)

right-arrow

1

Xiaolin Wu, Joshua Jebaraj Raymond, Yaoping Liu, Alexander Jeremias Odermatt, Wei-Xiang Sin, Denise Teo, Inn Chuan Ng, Michael Birnbaum, Timothy Lu, Jongyoon Han, Stacy Springs* and Hanry Yu*.

Multiplex Detection of Low Abundance Live Microorganisms Contamination in CAR-T cell manufacture using a Quantitative Digital Loop-mediated Isothermal Amplification Method

2023 Annual Conference of the Biomedical Engineering Society (BMES2023), Seattle, WA, USA.

SMART CAMP Authors

Read Publication (External Link)

right-arrow

1

Joshua Raymond, Xiaolin Wu, Yaoping Liu, Alexander Jeremias Odermatt, Wei-Xiang Sin, Denise Teo, Michael Birnbaum, Timothy Lu , Jongyoon Han, Stacy Springs, Hanry Yu

Multiplex Detection of Low Abundance Live Microorganisms Contamination in CAR-T cell manufacture using a Quantitative Digital Loop-mediated Isothermal Amplification Method

Singapore Cell & Gene Therapy Conference 2023, Singapore

SMART CAMP Authors

Read Publication (External Link)

right-arrow

1

Cheryl CHAN, Joanne LOH, Wei-Xiang SIN, Denise TEO, Michael BIRNBAUM, Rohan WILLIAMS, Stacy L. SPRINGS

One-day Cell-free Viral RNA Test for Detecting Adventitious Viruses and Endogenous Viral Reactivation

Singapore Cell & Gene Therapy Conference 2023, Singapore

SMART CAMP Authors

Read Publication (External Link)

right-arrow

1

Nicholas Ng Zhi Heng, Kerwin Kwek Zeming, Kai Yun Quek, Francesca Loraine Lim, Yunxin Chen, Chin Ren Goh, Faye Cheung Ka Wai, Sin Wei Xiang, Michael E. Birnbaum, Jongyoon Han

Rapid Label-Free Profiling and CAR-T Biophysical Morphologies for Continuous Monitoring

Singapore Cell & Gene Therapy Conference 2023, Singapore

SMART CAMP Authors

Read Publication (External Link)

right-arrow

1

Nicholas Tan Kwan Zen, Kerwin Kwek Zeming, Kai Yun Quek, Francesca Loraine Lim, Yunxin Chen, Chin Ren Goh, Nicholas Ng Zhi Heng, Michael E. Birnbaum, Jongyoon Han

Rapid Assessment of immunological response in post-infusion CAR-T patients using biophysical WBC analysis

Singapore Cell & Gene Therapy Conference 2023, Singapore

SMART CAMP Authors

Read Publication (External Link)

right-arrow

1

Kerwin Kwek Zeming, Kai Yun Quek, Wei-Xiang Sin, Ka-Wai Cheung, Michael E. Birnbaum, Jongyoon Han

Rapid Label-free Microfluidic Assay for Profiling Functional Phenotypes of CAR T Cells: Towards Enhanced Manufacturing Control

Singapore Cell & Gene Therapy Conference 2023, Singapore

SMART CAMP Authors

Read Publication (External Link)

right-arrow

1

Wei-Xiang SIN (SMART), Denise TEO (SMART), Kevin S. LEE (Erbi Biosystems Inc), Harry LEE (Erbi Biosystems Inc), Narendra Suhas JAGANNATHAN (Duke-NUS), Rajeev RAM (MIT), Lisa TUCKER-KELLOGG (Duke-NUS), Michael BIRNBAUM (MIT)

High Density CAR T Cell Culture with a 2-mL Continuous Perfusion Bioreactor

14th Stem Cell Society Singapore Symposium 2022, Singapore

SMART CAMP Authors

Read Publication (External Link)

right-arrow

1

Wei-Xiang SIN (SMART), Faye CHEUNG (SMART), Sandy LEE (A*STAR SIgN), Dedy SANDIKIN (SMART), Denise TEO (SMART), Faris KAIRI (SMART), Cheng-I WANG (A*STAR SIgN), Michael BIRNBAUM (MIT)

Characterization of LVV-Transduced, In Vitro-Expanded Anti-TIM3 CAR T Cells

14th Stem Cell Society Singapore Symposium 2022, Singapore

SMART CAMP Authors

Read Publication (External Link)

right-arrow

1

Kevin S. Lee (Erbi Biosystems Inc.), Wei-Xiang Sin (SMART), Michael Birnbaum (MIT)

Cell therapy process development with a 2 mL continuous perfusion bioreactor

27th ESACT Meeting, Lisbon, Portugal

SMART CAMP Authors

Read Publication (External Link)

right-arrow

1

Wei-Xiang Sin (SMART), Kevin S. Lee (Erbi Biosystems Inc.), Harry Lee (Erbi Biosystems Inc.), Michael Birnbaum (MIT)

High density CAR T cell culture with a 2 mL continuous perfusion bioreactor

SDCT-REMEDIS Cell Therapy Conference, Virtual (Singapore)

SMART CAMP Authors

Read Publication (External Link)

right-arrow

1

Kevin S. Lee (Erbi Biosystems Inc, Wei-Xiang Sin (SMART), Harry Lee (Erbi Biosystems Inc.), Michael Birnbaum (MIT)

Erbi Biosystems - Cell culture development with a 2 mL continuous perfusion bioreactor

Advancing Manufacture of Cell and Gene Therapies VII, Engineering Conference International, Coronado, CA, USA

SMART CAMP Authors

Read Publication (External Link)

right-arrow

Latest News

right arrowright-arrow
News

Jun 27, 2024

SMART CAMP Researchers Pioneer Production of CAR T-Cells Using High-Density Microfluidic Bioreactor

News

May 28, 2024

SMART discovers novel method to predict effectiveness of mesenchymal stromal cells (MSCs) for cartilage repair

Media/Press Release

May 10, 2024

Secret Singapore: Designing The Future Of Wellness

Nov 29, 2023

CAMP researchers present their research work at 15TH STEM CELL SOCIETY SINGAPORE SYMPOSIUM 2023; "STEM CELL INNOVATIONS IN RESEARCH AND HEALTHCARE"

Nov 28, 2023

New contamination-detection test to improve T-cell therapy

Nov 15, 2023

SMART pioneers microfluidic method to optimise stem cell extraction for advanced cell therapies

2023

Oct 19, 2023

Best Oral Presentation Award to Jerome Tan at “Tissue Engineering and Regenerative Medicine – Asia Pacific” Conference, Hong Kong

Sep 29, 2023

The people behind SMART CAMP: James Strutt, Senior Postdoctoral Researcher

Media/Press Release

Jun 9, 2023

Generation Next: New Era of Excellence

Copyright ©2023 SMART CAMP