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Xiaolin joined SMART-CAMP-IRG in December 2019. She holds a PhD in Biochemistry and Molecular Biology and a B.Sc in Pharmaceutical Science from Wuhan University. Her Ph.D. research was on DNA epigenetic modification in bacteria. She has previously been a visiting PhD student at MIT andSMART-AMR-IRG for 2.5 years, where she worked on DNA modification mechanism in bacteria and developing DNA sequencing methods to map DNA modification sites. Her research interests include CRISPR/Cas-based molecular detection methods andt he development of novel DNA/RNA detection and sequencing technologies.
Xiaolin is currently focusing on developing novel methods for the detection of adventitious agents in cell therapy processes. Cell therapies, like other biologics, are vulnerable to contamination with adventitious agents such as bacteria and viruses. Existing adventitious agents detection methods can take days, so Xiaolin is striving to develop new methods to speed up the safety control process. To this end, she has developed RApid DIgital Crispr Approaches (RADICA), an isothermal method for the detection and absolute quantification of DNA in hours. This method has been used to detect SARS-CoV-2,Epstein-Barr virus, human adenoviruses, and herpes simplex virus. Xiaolin is now exploring ways to expand the multiplex capabilities of the method and integrate it into CAR-T cell safety QC workflows.
Website (External Link)
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Y. Liu (SMART), J. Raymond (SMART), X. Wu (SMART), P. Chua (SMART), S. Ling SMART), C. C. Chan (SMART), C. Chan (SMART), J. Loh (SMART), M. Song (Ng Ann Poly), M. Ong (Ng Ann Poly), P. Ho (SMART), M. E. McBee (SMART), S. Springs (MIT/SMART), H. Yu (NUS) and J. Han (MIT/SMART),
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Wei-Xiang Sin (SMART), N. Suhas Jagannathan (SMART), Denise Bei Lin Teo (SMART), Faris Kairi (SMART), Shin Yie Fong (ASTAR-IMCB), Joel Heng Loong Tan (ASTAR-IMCB), Dedy Sandikin (SMART), Ka-Wai Cheung (SMART), Yen Hoon Luah (SMART), Xiaolin Wu (SMART), Joshua Jebaraj Raymond (SMART), Francesca Lorraine Wei Inng Lim (ACTRIS/SGH), Yie Hou Lee (SMART), Michaela Su-Fern Seng (SingHealth), Shui Yen Soh (SingHealth), Qingfeng Chen (ASTAR-IMCB), Rajeev J. Ram (SMART/MIT), Lisa Tucker-Kellogg (Duke-NUS) & Michael E. Birnbaum (SMART/MIT)
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Xiaolin Wu (SMART), Xuanming Lou (NUS), Hanzhang Zhou (NUS), Joshua Jebaraj Raymond (SMART), Leng Gek Kwang (NUS), Francesca Yi Teng Ong (NUS), Stacy L. Springs (MIT/SMART), Hanry Yu (NUS/SMART))
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Xiaolin Wu , Cheryl Chan, Stacy L. Springs, Yie Hou Lee, Timothy K. Lu, Hanry Yu
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Xiaolin Wu, Joshua K. Tay, Chuan Keng Goh, Cheryl Chan, Yie Hou Lee, Stacy L. Springs, De Yun Wang, Kwok Seng Loh, Timothy K. Lu, Hanry Yu
SMART CAMP Authors
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Sin, WX. (SMART), Jagannathan, N.S.(SMART, Duke-NUS), Teo, D.B.L. (SMART), Kairi F. (SMART), Fong S.Y. (IMCB, A*STAR), Tan J.H.L.** (IMCB, A*STAR), Sandikin D. (SMART), Cheung K.W.** (SMART), Luah Y.H.** (SMART), Wu X.** (SMART), Raymond J.J. (SMART), Lim F.L.W.I. (SGH, SingHealth), Lee Y.H. (SMART), Seng M.S.F. (KKH, SingHealth), Soh S.Y. (KKH, SingHealth), Chen Q. (IMCB, A*STAR), Ram R.J. (MIT), Tucker-Kellogg L. (Duke-NUS), Birnbaum M.E. (MIT)
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Xiaolin Wu, Joshua Raymond, Cheryl Chan, Yaoping Liu, Yie Hou Lee, Timothy Lu, Stacy Springs, Hanry Yu
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Xiaolin Wu, Joshua Raymond, Cheryl Chan, Yaoping Liu, Yie Hou Lee, Timothy Lu, Stacy Springs*, Hanry Yu*.
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Xiaolin Wu, Joshua Jebaraj Raymond, Yaoping Liu, Alexander Jeremias Odermatt, Wei-Xiang Sin, Denise Teo, Inn Chuan Ng, Michael Birnbaum, Timothy Lu, Jongyoon Han, Stacy Springs* and Hanry Yu*.
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Xiaolin Wu, Joshua Raymond, Cheryl Chan, Yaoping Liu, Yie Hou Lee, Timothy Lu, Stacy Springs, Hanry Yu
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Joshua Raymond, Xiaolin Wu, Yaoping Liu, Alexander Jeremias Odermatt, Wei-Xiang Sin, Denise Teo, Michael Birnbaum, Timothy Lu , Jongyoon Han, Stacy Springs, Hanry Yu
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Yaoping Liu, Sharon Yan Han Ling, Patrina Wei Lin Chua, Joshua Raymond, Xiaolin Wu, James Strutt, Peiying Ho, Megan Mcbee, Rohan Williams, Stacy L. Springs, Timothy K. Lu and Jongyoon Han
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Joshua Raymond (SMART), Xiaolin Wu (SMART), Yaoping Liu (SMART), Jongyoon Han (MIT), Timothy Lu (MIT), Hanry Yu (NUS)
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Yaoping Liu (SMART), Joshua Raymond (SMART), Xiaolin Wu (SMART), Stacy L. Springs (MIT), Timothy K. Lu (MIT), Hanry Yu (NUS) and Jongyoon Han (MIT, SMART)
SMART CAMP Authors