Yang Yanmeng obtained her Bachelor ofBiological Science in 2018, from Chu Kochen Honors College, Zhejiang University. Then she joined Prof. Lee Eng Hin’s laboratory as a Ph.D. candidate of Yong Loo Lin School of Medicine in National University of Singapore and obtained the Ph.D. degree in 2022. She is now a postdoctoral research associate at SMART-CAMP.

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She is a stem cell researcher with four years of experience in the field of preclinical and translational studies. Her research interests include stem cell therapy, cell manufacturing and cells ecretome, especially extracellular vesicles.

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Her current project is to validate the in-vitro critical quality attribute (CQA) and process analytical technology (PAT) for mesenchymal stem manufacturing in preclinical animal models.

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1)    Currently, the magnetic resonance relaxometry (MRR) technology has been found as novel efficacy CQA and PAT to predict chondrogenic potential of MSC in vitro.To further validate the link between MRR and MSC in vivo therapeutic effect, a rat osteoxchondral defect model will be used.

2)    A label-free, high-through-put, size-based segregation of MSC with inertial spiral micro channel has been investigated to isolate functionally specific MSC, which showed medium size and enhanced chondrogenic potential as well as paracrine activities. Moreover, gene expression analysis of medium size MSCs showed enriched immunomodulation - related pathways when compared to large size MSCs, which suggesting a potential application of selected MSCs in immune disease. Inthis study, a rat osteoarthritis model will be used.

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